IFCC methods for the measurement of catalytic concentration of enzymes. Part 8. IFCC method for lactate dehydrogenase (L-lactate: NAD+ oxidoreductase, EC 1.1.1.27)

摘要

Human lactate dehydrogenase is a tetramer made up of two typesof subunits, either H (heart) or M (muscle). Combination of thesesubunits gives rise to the five isoenzymes of lactate dehydrogenasewhich are found in mammalian tissues. The relative proportionsof the individual isoenzymes found in serum of patients is relatedto the severity of the lesion in the organ or tissue from which theyoriginate and the half-life of the individual tissue-specific enzymes.Thus, one cannot predict the relative proportions of the differentisoenzymes in any one patient sample.